Phosphorylation of the RNA Polymerase II Carboxyl-Terminal Domain by CDK9 Is Directly Responsible for Human Immunodeficiency Virus Type 1 Tat-Activated Transcriptional Elongation

Stimulation of transcriptional elongation by the human immunodeficiency virus type 1 Tat protein is mediated by CDK9, a kinase that phosphorylates the RNA polymerase II carboxyl-terminal domain (CTD). In order to obtain direct evidence that this phosphorylation event can alter RNA polymerase process...

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Detalhes bibliográficos
Main Authors: Kim, Young Kyeung, Bourgeois, Cyril F., Isel, Catherine, Churcher, Mark J., Karn, Jonathan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Transcriptional Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133925/
https://ncbi.nlm.nih.gov/pubmed/12052871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.13.4622-4637.2002
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