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Phosphorylation of the RNA Polymerase II Carboxyl-Terminal Domain by CDK9 Is Directly Responsible for Human Immunodeficiency Virus Type 1 Tat-Activated Transcriptional Elongation

Stimulation of transcriptional elongation by the human immunodeficiency virus type 1 Tat protein is mediated by CDK9, a kinase that phosphorylates the RNA polymerase II carboxyl-terminal domain (CTD). In order to obtain direct evidence that this phosphorylation event can alter RNA polymerase process...

Celý popis

Uloženo v:
Vydáno v:Mol Cell Biol
Hlavní autoři: Kim, Young Kyeung, Bourgeois, Cyril F., Isel, Catherine, Churcher, Mark J., Karn, Jonathan
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2002
Témata:
Transcriptional Regulation
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133925/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12052871/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.13.4622-4637.2002
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