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Elevated blood pressures in mice lacking endothelial nitric oxide synthase

Nitric oxide produced in endothelial cells affects vascular tone. To investigate the role of endothelial nitric oxide synthase (eNOS) in blood pressure regulation, we have generated mice heterozygous (+/−) or homozygous (−/−) for disruption of the eNOS gene. Immunohistochemical staining with anti-eN...

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Detalhes bibliográficos
Main Authors: Shesely, Edward G., Maeda, Nobuyo, Kim, H.-S., Desai, Kaushik M., Krege, John H., Laubach, Victor E., Sherman, Paula A., Sessa, William C., Smithies, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1996
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC24066/
https://ncbi.nlm.nih.gov/pubmed/8917564
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