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Evidence that the 42- and 40-amino acid forms of amyloid β protein are generated from the β-amyloid precursor protein by different protease activities

Cerebral deposition of the amyloid β protein (Aβ) is an early and invariant feature of Alzheimer disease (AD). Whereas the 40-amino acid form of Aβ (Aβ(40)) accounts for ≈90% of all Aβ normally released from cells, it appears to contribute only to later phases of the pathology. In contrast, the long...

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Detaylı Bibliyografya
Asıl Yazarlar: Citron, Martin, Diehl, Thekla S., Gordon, Grace, Biere, Anja Leona, Seubert, Peter, Selkoe, Dennis J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences of the USA 1996
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC24065/
https://ncbi.nlm.nih.gov/pubmed/8917563
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