Potential role for herpes simplex virus ICP8 DNA replication protein in stimulation of late gene expression.
We have identified a trans-dominant mutant form of the herpes simplex virus (HSV) DNA-binding protein ICP8 which inhibits viral replication. When expressed by the V2.6 cell line, the mutant gene product inhibited wild-type HSV production by 50- to 150-fold when the multiplicity of infection was less...
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| Опубликовано в:: | J Virol |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology (ASM)
1991
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240625/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1850040/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.5.2666-2675.1991 |
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