Potential role for herpes simplex virus ICP8 DNA replication protein in stimulation of late gene expression.

We have identified a trans-dominant mutant form of the herpes simplex virus (HSV) DNA-binding protein ICP8 which inhibits viral replication. When expressed by the V2.6 cell line, the mutant gene product inhibited wild-type HSV production by 50- to 150-fold when the multiplicity of infection was less...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Gao, M, Knipe, D M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1991
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240625/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1850040/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.5.2666-2675.1991
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!