Potential role for herpes simplex virus ICP8 DNA replication protein in stimulation of late gene expression.

We have identified a trans-dominant mutant form of the herpes simplex virus (HSV) DNA-binding protein ICP8 which inhibits viral replication. When expressed by the V2.6 cell line, the mutant gene product inhibited wild-type HSV production by 50- to 150-fold when the multiplicity of infection was less...

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Vydáno v:	J Virol
Hlavní autoři:	Gao, M, Knipe, D M
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1991
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240625/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1850040/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.5.2666-2675.1991
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