Purification and characterization of poliovirus polypeptide 3CD, a proteinase and a precursor for RNA polymerase.

A cDNA clone encoding the 3CD proteinase (3CDpro) of poliovirus type 2 (Sabin), the precursor to proteinase 3Cpro and RNA polymerase 3Dpol, was expressed in bacteria by using a T7 expression system. Site-specific mutagenesis of the 3C/3D cleavage site was performed to generate active proteolytic pre...

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Bibliografiska uppgifter
Huvudupphovsmän: Harris, K S, Reddigari, S R, Nicklin, M J, Hämmerle, T, Wimmer, E
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1992
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC240456/
https://ncbi.nlm.nih.gov/pubmed/1331532
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