Functional characterization of temperature-sensitive mutants of simian virus 40 large T antigen.

We investigated the molecular properties of eight temperature-sensitive mutants of simian virus 40 large T antigen (tsA mutants). The mutants have single amino acid substitutions that block DNA replication at 39 to 41 degrees C in vivo. In vitro, five of the mutant proteins were highly sensitive to...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Ray, S, Anderson, M E, Loeber, G, McVey, D, Tegtmeyer, P
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1992
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240144/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1328677/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.11.6509-6516.1992
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!