Functional characterization of temperature-sensitive mutants of simian virus 40 large T antigen.

We investigated the molecular properties of eight temperature-sensitive mutants of simian virus 40 large T antigen (tsA mutants). The mutants have single amino acid substitutions that block DNA replication at 39 to 41 degrees C in vivo. In vitro, five of the mutant proteins were highly sensitive to...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Ray, S, Anderson, M E, Loeber, G, McVey, D, Tegtmeyer, P
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240144/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1328677/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.11.6509-6516.1992
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