Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro.

We have probed the structural organization of the human immunodeficiency virus type 1 integrase protein by limited proteolysis and the functional organization by site-directed mutagenesis of selected amino acid residues. A central region of the protein was relatively resistant to proteolysis. Protei...

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Εκδόθηκε σε:	J Virol
Κύριοι συγγραφείς:	Engelman, A, Craigie, R
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society for Microbiology (ASM) 1992
Θέματα:	Research Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240128/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1404595/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.11.6361-6369.1992
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