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Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication.

The integration of a DNA copy of the human immunodeficiency virus type 1 (HIV-1) genome into a chromosome of an infected cell is a pivotal step in virus replication. Integration requires the activity of the virus-encoded integrase, which enters the cell as a component of the virion. Results of numer...

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Detalhes bibliográficos
Main Authors: Engelman, A, Englund, G, Orenstein, J M, Martin, M A, Craigie, R
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC188965/
https://ncbi.nlm.nih.gov/pubmed/7535863
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