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Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro.

We have probed the structural organization of the human immunodeficiency virus type 1 integrase protein by limited proteolysis and the functional organization by site-directed mutagenesis of selected amino acid residues. A central region of the protein was relatively resistant to proteolysis. Protei...

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Bibliografske podrobnosti
Main Authors: Engelman, A, Craigie, R
Format: Artigo
Jezik:Inglês
Izdano: 1992
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC240128/
https://ncbi.nlm.nih.gov/pubmed/1404595
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