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Structures of DNA Polymerase β with Active Site Mismatches Suggest a Transient Abasic Site Intermediate During Misincorporation
We report the crystallographic structures of DNA polymerase β with dG—dAMPCPP and dC— dAMPCPP mismatches in the active site. These pre-mutagenic structures were obtained with a non-hydrolysable incoming nucleotide analog, dAMPCPP, and Mn(+2). Substituting Mn(2+) for Mg(2+) significantly decreases th...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2399898/ https://ncbi.nlm.nih.gov/pubmed/18471977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.02.025 |
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