X-ray Crystallographic Studies of Substrate Binding to Aristolochene Synthase Suggest a Metal Ion Binding Sequence for Catalysis

The universal sesquiterpene precursor, farnesyl diphosphate (FPP), is cyclized in an Mg(2+)-dependent reaction catalyzed by the tetrameric aristolochene synthase from Aspergillus terreus to form the bicyclic hydrocarbon aristolochene and a pyrophosphate anion (PP(i)) coproduct. The 2.1-Å resolution...

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Bibliographic Details
Main Authors: Shishova, Ekaterina Y., Yu, Fanglei, Miller, David J., Faraldos, Juan A., Zhao, Yuxin, Coates, Robert M., Allemann, Rudolf K., Cane, David E., Christianson, David W.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Enzyme Catalysis and Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2397452/
https://ncbi.nlm.nih.gov/pubmed/18385128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800659200
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