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Pathway and Endpoint Free Energy Calculations for Cyclic Nucleotide Binding to HCN Channels
cAMP and cGMP differentially bind to and regulate a variety of proteins, including cyclic nucleotide-gated (CNG) channels and hyperpolarization-activated cyclic nucleotide-regulated (HCN) channels. Previous site-directed mutagenesis studies have isolated two conserved residues that are critical for...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2397330/ https://ncbi.nlm.nih.gov/pubmed/18408037 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.130872 |
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