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Endothelin-1 Couples βPix to p66Shc: Role of βPix in Cell Proliferation through FOXO3a Phosphorylation and p27(kip1) Down-Regulation Independently of Akt

The phosphorylation of forkhead transcription factor FOXO3a by Akt is critical regulator of cell proliferation induced by serum. We show that endothelin-1 (ET-1) stimulation of primary human mesangial cells (HMCs) induces βPix and p66Shc up-regulation, resulting in the formation of the βPix/p66Shc c...

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Библиографические подробности
Главные авторы: Chahdi, Ahmed, Sorokin, Andrey
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Cell Biology 2008
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2397323/
https://ncbi.nlm.nih.gov/pubmed/18385518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-05-0424
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