Endothelin-1 Inhibits the Epithelial Na(+) Channel through βPix/14-3-3/Nedd4-2

Epithelial Na(+) channels (ENaCs) mediate sodium reabsorption in the cortical collecting duct (CCD), but the regulatory pathways that modulate the activity of these channels are incompletely understood. Here, we observed that endothelin-1 (ET-1) attenuates ENaC activity acutely by reducing the chann...

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Detalhes bibliográficos
Main Authors: Pavlov, Tengis S., Chahdi, Ahmed, Ilatovskaya, Daria V., Levchenko, Vladislav, Vandewalle, Alain, Pochynyuk, Oleh, Sorokin, Andrey, Staruschenko, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2010
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865733/
https://ncbi.nlm.nih.gov/pubmed/20338996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009080885
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