EGFR Activation Increases Parathyroid Hyperplasia and Calcitriol Resistance in Kidney Disease

Calcitriol, acting through vitamin D receptors (VDR) in the parathyroid, suppresses parathyroid hormone synthesis and cell proliferation. In secondary hyperparathyroidism (SH), VDR content is reduced as hyperplasia becomes more severe, limiting the efficacy of calcitriol. In a rat model of SH, activ...

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Detaylı Bibliyografya
Asıl Yazarlar: Arcidiacono, Maria Vittoria, Sato, Tetsuhiko, Alvarez-Hernandez, Daniel, Yang, Jing, Tokumoto, Masanori, Gonzalez-Suarez, Ignacio, Lu, Yan, Tominaga, Yoshihiro, Cannata-Andia, Jorge, Slatopolsky, Eduardo, Dusso, Adriana S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Nephrology 2008
Konular:
Basic Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396751/
https://ncbi.nlm.nih.gov/pubmed/18216322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2007040406
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