EGFR Activation Increases Parathyroid Hyperplasia and Calcitriol Resistance in Kidney Disease

Calcitriol, acting through vitamin D receptors (VDR) in the parathyroid, suppresses parathyroid hormone synthesis and cell proliferation. In secondary hyperparathyroidism (SH), VDR content is reduced as hyperplasia becomes more severe, limiting the efficacy of calcitriol. In a rat model of SH, activ...

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Hlavní autoři: Arcidiacono, Maria Vittoria, Sato, Tetsuhiko, Alvarez-Hernandez, Daniel, Yang, Jing, Tokumoto, Masanori, Gonzalez-Suarez, Ignacio, Lu, Yan, Tominaga, Yoshihiro, Cannata-Andia, Jorge, Slatopolsky, Eduardo, Dusso, Adriana S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2008
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396751/
https://ncbi.nlm.nih.gov/pubmed/18216322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2007040406
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