EGFR Activation Increases Parathyroid Hyperplasia and Calcitriol Resistance in Kidney Disease

Calcitriol, acting through vitamin D receptors (VDR) in the parathyroid, suppresses parathyroid hormone synthesis and cell proliferation. In secondary hyperparathyroidism (SH), VDR content is reduced as hyperplasia becomes more severe, limiting the efficacy of calcitriol. In a rat model of SH, activ...

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Detalhes bibliográficos
Main Authors: Arcidiacono, Maria Vittoria, Sato, Tetsuhiko, Alvarez-Hernandez, Daniel, Yang, Jing, Tokumoto, Masanori, Gonzalez-Suarez, Ignacio, Lu, Yan, Tominaga, Yoshihiro, Cannata-Andia, Jorge, Slatopolsky, Eduardo, Dusso, Adriana S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2008
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396751/
https://ncbi.nlm.nih.gov/pubmed/18216322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2007040406
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