Activator Protein 2α Mediates Parathyroid TGF-α Self-Induction in Secondary Hyperparathyroidism

In secondary hyperparathyroidism, enhanced expression of TGF-α in the parathyroid leads to its own upregulation, generating a feed-forward loop for TGF-α activation of its receptor, EGFR receptor (EGFR), which promotes parathyroid hyperplasia. These studies examined the role of activator protein 2α...

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Autori principali: Arcidiacono, Maria Vittoria, Cozzolino, Mario, Spiegel, Noah, Tokumoto, Masanori, Yang, Jing, Lu, Yan, Sato, Tetsuhiko, Lomonte, Carlo, Basile, Carlo, Slatopolsky, Eduardo, Dusso, Adriana S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2008
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2551566/
https://ncbi.nlm.nih.gov/pubmed/18579641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2007111216
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