EGFR Activation Increases Parathyroid Hyperplasia and Calcitriol Resistance in Kidney Disease

Calcitriol, acting through vitamin D receptors (VDR) in the parathyroid, suppresses parathyroid hormone synthesis and cell proliferation. In secondary hyperparathyroidism (SH), VDR content is reduced as hyperplasia becomes more severe, limiting the efficacy of calcitriol. In a rat model of SH, activ...

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Bibliographische Detailangaben
Hauptverfasser: Arcidiacono, Maria Vittoria, Sato, Tetsuhiko, Alvarez-Hernandez, Daniel, Yang, Jing, Tokumoto, Masanori, Gonzalez-Suarez, Ignacio, Lu, Yan, Tominaga, Yoshihiro, Cannata-Andia, Jorge, Slatopolsky, Eduardo, Dusso, Adriana S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Nephrology 2008
Schlagworte:
Basic Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396751/
https://ncbi.nlm.nih.gov/pubmed/18216322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2007040406
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