EGFR Activation Increases Parathyroid Hyperplasia and Calcitriol Resistance in Kidney Disease

Calcitriol, acting through vitamin D receptors (VDR) in the parathyroid, suppresses parathyroid hormone synthesis and cell proliferation. In secondary hyperparathyroidism (SH), VDR content is reduced as hyperplasia becomes more severe, limiting the efficacy of calcitriol. In a rat model of SH, activ...

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Bibliografiske detaljer
Main Authors: Arcidiacono, Maria Vittoria, Sato, Tetsuhiko, Alvarez-Hernandez, Daniel, Yang, Jing, Tokumoto, Masanori, Gonzalez-Suarez, Ignacio, Lu, Yan, Tominaga, Yoshihiro, Cannata-Andia, Jorge, Slatopolsky, Eduardo, Dusso, Adriana S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2008
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396751/
https://ncbi.nlm.nih.gov/pubmed/18216322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2007040406
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