Analysis of siRNA specificity on targets with double-nucleotide mismatches

Although RNA interference as a tool for gene knockdown is a great promise for future applications, the specificity of small interfering RNA (siRNA)-mediated gene silencing needs to be thoroughly investigated. Most research regarding siRNA specificity has involved analysis of affected off-target gene...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Dahlgren, Cecilia, Zhang, Hong-Yan, Du, Quan, Grahn, Maria, Norstedt, Gunnar, Wahlestedt, Claes, Liang, Zicai
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2008
Schlagworte:
Methods Online
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396434/
https://ncbi.nlm.nih.gov/pubmed/18420656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn190
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