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Analysis of siRNA specificity on targets with double-nucleotide mismatches
Although RNA interference as a tool for gene knockdown is a great promise for future applications, the specificity of small interfering RNA (siRNA)-mediated gene silencing needs to be thoroughly investigated. Most research regarding siRNA specificity has involved analysis of affected off-target gene...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2396434/ https://ncbi.nlm.nih.gov/pubmed/18420656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn190 |
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