Pyrrole-imidazole hairpin polyamides with high affinity at 5′–CGCG–3′ DNA sequence; influence of cytosine methylation on binding

To investigate the binding of 5′–CpG–3′ sequences by small molecules, two pyrrole (Py)–imidazole (Im) hairpin polyamides, PyImPyIm–γ–PyImPyIm–β–Dp (1) and PyIm–β–Im–γ–PyIm–β–Im–β–Dp (2), which recognize the sequence 5′–CGCG–3′, were synthesized. The binding affinities of the 5′–CGCG–3′ sequence to t...

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Bibliografske podrobnosti
Main Authors: Minoshima, Masafumi, Bando, Toshikazu, Sasaki, Shunta, Fujimoto, Jun, Sugiyama, Hiroshi
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2008
Teme:
Chemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396430/
https://ncbi.nlm.nih.gov/pubmed/18385159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn116
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