Understanding how the V(D)J recombinase catalyzes transesterification: distinctions between DNA cleavage and transposition

The Rag1 and Rag2 proteins initiate V(D)J recombination by introducing site-specific DNA double-strand breaks. Cleavage occurs by nicking one DNA strand, followed by a one-step transesterification reaction that forms a DNA hairpin structure. A similar reaction allows Rag transposition, in which the...

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Bibliographic Details
Main Authors: Lu, Catherine P., Posey, Jennifer E., Roth, David B.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2008
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396405/
https://ncbi.nlm.nih.gov/pubmed/18375979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn128
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