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In vivo transposition mediated by V(D)J recombinase in human T lymphocytes
The rearrangement of immunoglobulin (Ig) and T-cell receptor (TCR) genes in lymphocytes by V(D)J recombinase is essential for immunological diversity in humans. These DNA rearrangements involve cleavage by the RAG1 and RAG2 (RAG1/2) recombinase enzymes at recombination signal sequences (RSS). This r...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC151080/ https://ncbi.nlm.nih.gov/pubmed/12628930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg137 |
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