Coreceptor Tropism Can Be Influenced by Amino Acid Substitutions in the gp41 Transmembrane Subunit of Human Immunodeficiency Virus Type 1 Envelope Protein

Many studies have demonstrated that the third variable region (V3) of the human immunodeficiency virus type 1 (HIV-1) envelope protein (Env) is a major determinant of coreceptor tropism. Other regions in the surface gp120 subunit of Env can modulate coreceptor tropism in a manner that is not fully u...

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Autori principali: Huang, Wei, Toma, Jonathan, Fransen, Signe, Stawiski, Eric, Reeves, Jacqueline D., Whitcomb, Jeannette M., Parkin, Neil, Petropoulos, Christos J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
Soggetti:
Virus-Cell Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2395220/
https://ncbi.nlm.nih.gov/pubmed/18353956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02676-07
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