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Poliovirus 2A(Pro) Increases Viral mRNA and Polysome Stability Coordinately in Time with Cleavage of eIF4G
Poliovirus (PV) 2A protease (2A(Pro)) cleaves eukaryotic initiation factors 4GI and 4GII (eIF4GI and eIF4GII) within virus-infected cells, effectively halting cap-dependent mRNA translation. PV mRNA, which does not possess a 5′ cap, is translated via cap-independent mechanisms within viral protease-...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2395153/ https://ncbi.nlm.nih.gov/pubmed/18400852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01514-07 |
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