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Poliovirus 2A(Pro) Increases Viral mRNA and Polysome Stability Coordinately in Time with Cleavage of eIF4G

Poliovirus (PV) 2A protease (2A(Pro)) cleaves eukaryotic initiation factors 4GI and 4GII (eIF4GI and eIF4GII) within virus-infected cells, effectively halting cap-dependent mRNA translation. PV mRNA, which does not possess a 5′ cap, is translated via cap-independent mechanisms within viral protease-...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kempf, Brian J., Barton, David J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2395153/
https://ncbi.nlm.nih.gov/pubmed/18400852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01514-07
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