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Dramatic Activation of Antibiotic Production in Streptomyces coelicolor by Cumulative Drug Resistance Mutations

We recently described a new method to activate antibiotic production in bacteria by introducing a mutation conferring resistance to a drug such as streptomycin, rifampin, paromomycin, or gentamicin. This method, however, enhanced antibiotic production by only up to an order of magnitude. Working wit...

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Bibliografiske detaljer
Main Authors: Wang, Guojun, Hosaka, Takeshi, Ochi, Kozo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2394871/
https://ncbi.nlm.nih.gov/pubmed/18310410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02800-07
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