A Novel Insertion Mutation in Streptomyces coelicolor Ribosomal S12 Protein Results in Paromomycin Resistance and Antibiotic Overproduction

We identified a novel paromomycin resistance-associated mutation in rpsL, caused by the insertion of a glycine residue at position 92, in Streptomyces coelicolor ribosomal protein S12. This insertion mutation (GI92) resulted in a 20-fold increase in the paromomycin resistance level. In combination w...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Wang, Guojun, Inaoka, Takashi, Okamoto, Susumu, Ochi, Kozo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology (ASM) 2009
Gaiak:
Chemistry; Biosynthesis
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650515/
https://ncbi.nlm.nih.gov/pubmed/19104019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00388-08
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