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Substantial improvement of toyocamycin production in Streptomyces diastatochromogenes by cumulative drug-resistance mutations

Toyocamycin is a member of the nucleoside antibiotic family and has been recognized as a promising fungicide for the control of plant diseases. However, low productivity of toyocamycin remains an important bottleneck in its industrial production. Therefore, dramatic improvements of strains for overp...

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Опубликовано в: :PLoS One
Главные авторы: Shentu, Xu-Ping, Cao, Zhen-Yan, Xiao, Yin, Tang, Gu, Ochi, Kozo, Yu, Xiao-Ping
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2018
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6117005/
https://ncbi.nlm.nih.gov/pubmed/30161195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0203006
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