Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms

Endocytosis and subsequent lysosomal degradation serve as a well characterized mechanism to fine-tune and down-regulate EGFR signaling. However, other members of the EGFR/ErbB receptor family have been reported to be endocytosis-impaired. Here we demonstrate that endocytosis of ErbB4 is regulated in...

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Autors principals: Sundvall, Maria, Korhonen, Anna, Paatero, Ilkka, Gaudio, Eugenio, Melino, Gerry, Croce, Carlo M., Aqeilan, Rami I., Elenius, Klaus
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2393780/
https://ncbi.nlm.nih.gov/pubmed/18334649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708333105
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