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IgG glycan hydrolysis by a bacterial enzyme as a therapy against autoimmune conditions
EndoS from Streptococcus pyogenes efficiently hydrolyzes the functionally important and conserved N-linked glycan of IgG in human blood. Repeated i.v. administration of EndoS in rabbits completely hydrolyzes the glycans of the whole IgG pool, despite the generation of anti-EndoS antibodies. EndoS ad...
Uloženo v:
| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2393778/ https://ncbi.nlm.nih.gov/pubmed/18332429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711271105 |
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