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KCNQ1 and KCNE1 in the I(Ks) Channel Complex Make State-dependent Contacts in their Extracellular Domains
KCNQ1 and KCNE1 (Q1 and E1) associate to form the slow delayed rectifier I(Ks) channels in the heart. A short stretch of eight amino acids at the extracellular end of S1 in Q1 (positions 140–147) harbors six arrhythmia-associated mutations. Some of these mutations affect the Q1 channel function only...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2391252/ https://ncbi.nlm.nih.gov/pubmed/18504315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200809976 |
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