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Gating-Related Molecular Motions in the Extracellular Domain of the I(Ks) Channel: Implications for I(Ks) Channelopathy
Cardiac slow delayed rectifier (I(Ks)) channel complex consists of KCNQ1 channel and KCNE1 auxiliary subunits. The extracellular juxtamembranous region of KCNE1 is an unstructured loop that contacts multiple KCNQ1 positions in a gating-state-dependent manner. Congenital arrhythmia-related mutations...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3893887/ https://ncbi.nlm.nih.gov/pubmed/21152909 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00232-010-9333-7 |
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