Ribonucleotide reductase subunits M1 and M2 mRNA expression levels and clinical outcome of lung adenocarcinoma patients treated with docetaxel/gemcitabine

Ribonucleotide reductase subunits M1 (RRM1) and M2 (RRM2) are involved in the metabolism of gemcitabine (2′,2′-difluorodeoxycytidine), which is used for the treatment of nonsmall cell lung cancer. The mRNA expression of RRM1 and RRM2 in tumours from lung adenocarcinoma patients treated with docetaxe...

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Hlavní autoři: Souglakos, J, Boukovinas, I, Taron, M, Mendez, P, Mavroudis, D, Tripaki, M, Hatzidaki, D, Koutsopoulos, A, Stathopoulos, E, Georgoulias, V, Rosell, R
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2008
Témata:
Genetics and Genomics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2391126/
https://ncbi.nlm.nih.gov/pubmed/18414411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604344
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