Midazolam metabolism in Cytochrome P450 3A knockout mice can be attributed to upregulated CYP2C enzymes

The cytochrome P450 3A (CYP3A) enzymes represent one of the most important drug-metabolizing systems in human. Recently, our group has generated cytochrome P450 3A knockout mice to study this drug-handling system in vivo. Here, we have characterized the Cyp3a knockout mice by studying the metabolism...

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Hauptverfasser: van Waterschoot, Robert A.B., van Herwaarden, Antonius E., Lagas, Jurjen S., Sparidans, Rolf W., Wagenaar, Els, van der Kruijssen, Cornelia M.M., Goldstein, Joyce A., Zeldin, Darryl C., Beijnen, Jos H., Schinkel, Alfred H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2391091/
https://ncbi.nlm.nih.gov/pubmed/18156313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.107.043869
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