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tPA Protects Renal Interstitial Fibroblasts and Myofibroblasts from Apoptosis

Activation and expansion of interstitial fibroblasts and myofibroblasts play an essential role in the evolution of renal fibrosis. After obstructive injury, mice lacking tissue-type plasminogen activator (tPA) have fewer myofibroblasts and less interstitial fibrosis than wild-type controls. This sug...

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Autors principals: Hu, Kebin, Lin, Ling, Tan, Xiaoyue, Yang, Junwei, Bu, Guojun, Mars, Wendy M., Liu, Youhua
Format: Artigo
Idioma:Inglês
Publicat: American Society of Nephrology 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2391054/
https://ncbi.nlm.nih.gov/pubmed/18199803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2007030300
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