tPA Activates LDL Receptor-Related Protein 1-Mediated Mitogenic Signaling Involving the p90RSK and GSK3β Pathway

In renal fibrosis, interstitial fibroblasts have an increased proliferative phenotype, and the numbers of interstitial fibroblasts closely correlate with the extent of kidney damage. The mechanisms underlying proliferation and resulting expansion of the interstitium remain largely unknown. Here we d...

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Bibliographic Details
Main Authors: Lin, Ling, Bu, Guojun, Mars, Wendy M., Reeves, W. Brian, Tanaka, Sakae, Hu, Kebin
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2010
Subjects:
Regular Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947266/
https://ncbi.nlm.nih.gov/pubmed/20724593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.100213
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