Rac1 activation and subsequent β-catenin phosphorylation controls nuclear localization of β-catenin during canonical Wnt signaling

Canonical Wnt signaling via β-catenin-dependent transcription critically regulates cell fate and proliferation in development and disease. However, mechanisms governing β-catenin nuclear localization are not well understood. Here we demonstrate that nuclear accumulation of β-catenin and gene activat...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wu, Ximei, Tu, Xiaolin, Joeng, Kyu Sang, Hilton, Matthew J., Williams, David A., Long, Fanxin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2008
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2390926/
https://ncbi.nlm.nih.gov/pubmed/18423204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.01.052
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