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Rac1 activation and subsequent β-catenin phosphorylation controls nuclear localization of β-catenin during canonical Wnt signaling
Canonical Wnt signaling via β-catenin-dependent transcription critically regulates cell fate and proliferation in development and disease. However, mechanisms governing β-catenin nuclear localization are not well understood. Here we demonstrate that nuclear accumulation of β-catenin and gene activat...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2390926/ https://ncbi.nlm.nih.gov/pubmed/18423204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.01.052 |
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