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Nucleoside modifications modulate activation of the protein kinase PKR in an RNA structure-specific manner
The human interferon-induced protein kinase PKR is a key component of innate immunity, a process in which it senses pathogenic RNA. PKR consists of an N-terminal dsRNA-binding domain (dsRBD) and a C-terminal kinase domain. Upon binding long (>33 base pairs) stretches of pathogenic dsRNA, PKR unde...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2390794/ https://ncbi.nlm.nih.gov/pubmed/18426922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1007408 |
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