cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo

Tissue engineering of large bone defects is approached through implantation of autologous osteogenic cells, generally referred to as multipotent stromal cells or mesenchymal stem cells (MSCs). Animal-derived MSCs successfully bridge large bone defects, but models for ectopic bone formation as well a...

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Bibliographische Detailangaben
Hauptverfasser: Siddappa, Ramakrishnaiah, Martens, Anton, Doorn, Joyce, Leusink, Anouk, Olivo, Cristina, Licht, Ruud, van Rijn, Linda, Gaspar, Claudia, Fodde, Riccardo, Janssen, Frank, van Blitterswijk, Clemens, de Boer, Jan
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2387183/
https://ncbi.nlm.nih.gov/pubmed/18490653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711190105
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