Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes

Understanding the mechanisms of multidrug resistance (MDR) could improve clinical drug efficacy. Multidrug resistance is associated with ATP binding cassette (ABC) transporters, but the factors that regulate their expression at clinically relevant drug concentrations are poorly understood. We report...

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Autors principals: Calcagno, A M, Fostel, J M, To, K K W, Salcido, C D, Martin, S E, Chewning, K J, Wu, C-P, Varticovski, L, Bates, S E, Caplen, N J, Ambudkar, S V
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2008
Matèries:
Translational Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386965/
https://ncbi.nlm.nih.gov/pubmed/18382425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604334
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