Indomethacin induces apoptosis via a MRP1-dependent mechanism in doxorubicin-resistant small-cell lung cancer cells overexpressing MRP1

Small-cell lung cancers (SCLCs) initially respond to chemotherapy, but are often resistant at recurrence. The non-steroidal anti-inflammatory drug indomethacin is an inhibitor of multidrug resistance protein 1 (MRP1) function. The doxorubicin-resistant MRP1-overexpressing human SCLC cell line GLC(4)...

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Detalhes bibliográficos
Main Authors: de Groot, D J A, van der Deen, M, Le, T K P, Regeling, A, de Jong, S, de Vries, E G E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360450/
https://ncbi.nlm.nih.gov/pubmed/17940500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604010
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