Design of an Active Ultrastable Single-chain Insulin Analog: SYNTHESIS, STRUCTURE, AND THERAPEUTIC IMPLICATIONS

Single-chain insulin (SCI) analogs provide insight into the inter-relation of hormone structure, function, and dynamics. Although compatible with wild-type structure, short connecting segments (<3 residues) prevent induced fit upon receptor binding and so are essentially without biological activi...

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Hlavní autoři: Hua, Qing-xin, Nakagawa, Satoe H., Jia, Wenhua, Huang, Kun, Phillips, Nelson B., Hu, Shi-quan, Weiss, Michael A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386938/
https://ncbi.nlm.nih.gov/pubmed/18332129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800313200
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