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Chiral Mutagenesis of Insulin. Foldability and Function Are Inversely Regulated by a Stereospecific Switch in the B Chain,
How insulin binds to its receptor is unknown despite decades of investigation. Here, we employ chiral mutagenesis–comparison of corresponding d and l amino acid substitutions in the hormone–to define a structural switch between folding-competent and active conformations. Our strategy is motivated by...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3845378/ https://ncbi.nlm.nih.gov/pubmed/15794637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi048025o |
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