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A cavity-forming mutation in insulin induces segmental unfolding of a surrounding α-helix
To investigate the cooperativity of insulin's structure, a cavity-forming substitution was introduced within the hydrophobic core of an engineered monomer. The substitution, Ile(A2)→Ala in the A1–A8 α-helix, does not impair disulfide pairing between chains. In accord with past studies of cavity...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2368773/ https://ncbi.nlm.nih.gov/pubmed/11742127 |
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