Wird geladen...
A cavity-forming mutation in insulin induces segmental unfolding of a surrounding α-helix
To investigate the cooperativity of insulin's structure, a cavity-forming substitution was introduced within the hydrophobic core of an engineered monomer. The substitution, Ile(A2)→Ala in the A1–A8 α-helix, does not impair disulfide pairing between chains. In accord with past studies of cavity...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2002
|
| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2368773/ https://ncbi.nlm.nih.gov/pubmed/11742127 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|